New Paths - New Ideas
Our research addresses signals used by cells to talk to each other and to organise themselves. To investigate these signals in action, we have developed over many years together with the Guber Lab at the Institute for Microstructure Technology (IMT) at the Campus Nord a microfluidic chip for plant cells. A molecule becomes a signal, when it "means" something to the recipient. Specificity arises in the eye of the recipient, therefore, and is result of a long evolutionary history. This holds true not only within an individual organism, but also between organisms. In frame of the Science Offensive of the Interreg Upper Rhine our research network DialogProTec explored this idea to find signals, by which fungi manipulate plant immunity to infect plants. Other signals are used by plants themselves to persuade competitors into suicide. Based on such signals, novel strategies for plant protection can be developed that are more sustainable, because they use chemical communication originating from evolution itself.
What came out from this project? A review in BioSpektrum.
Cellular Biotechnology
What is it about?
Each individual plant cell can generate an entire organism. We cannot do that. Central for this ability is an internal "direction" of the individual cell. This direction is continuously adjusted. When a multicellular plant body forms, the cytoskeleton is aligned in response to chemical oscillations. How is this "direction" generated? Why is it continuosly "questioned"? How do individual cells join into an entity? Can we join plant cells to play "metabolic LEGO"? How can a cell sense, whether it is still intact? How does cell architectur define its molecular activities?
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Cell and OrganismPlant cells organise into an entity. Axis and direction of the cell are ruled by the cytoskeleton, but plants can also integrate signals from the environment, such as light. How does this work?
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Metabolic LEGOPlants can generate numerous compounds, the impact on medicine is tremendous. This ability is based on a kind of chemical teamwork. Can we simulate this for biotechnology to safeguard endangered plants from extinction
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Integrity SensingA flow of signals between membrane and cytoskeleton allow the cell to sense, whether it is still intact. Using novel methodology such as nanosecond bioelectris or chemical engineering we can manipulate this flow. |
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Form Rules MatterThe causa formalis is one of the four Aristotelian Causes (besides effect, matter, and purpose). We investigate, how plant cells adjust their inner architecture to steer molecular events.
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Zellskelett und RichtungAchse und Richtung der Zelle wird über ein sich ständig wandelndes Geflecht von Proteinfasern, dem Zellskelett, gelenkt. Wie wird festgelegt, wo es entsteht und in welcher Richtung es wächst?
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Metabolisches LEGOPflanzen können eine Vielzahl von Stoffen erzeugen, die Bedeutung für die Medizin ist riesig. Das funktioniert über eine Art chemischer Teamarbeit. Können wir das biotechnologisch nachbilden, um so bedrohte Pflanzen vor der Ausrottung zu schützen?
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Wahrnehmung von IntegritätÜber einen Fluss von Signalen zwischen Membran und Cytoskelett misst die Zelle, ob sie intakt ist. Mit neuen Methoden wie Nanosekunden-Elektrik oder chemical engineering können wir diesen Fluss manipulieren. |
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Form regiert MaterieDie causa formalis ist eine der vier Aristotelischen Ursachen (neben Wirkung, Materie und Zweck). Wir untersuchen, wie Pflanzenzellen über Änderungen ihrer inneren Architektur molekulare Vorgänge steuern.
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